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About Febrile Neutropenia

Neutropenia can affect patients and their treatment in many ways. Clinical studies have shown that neutropenia can interrupt chemotherapy treatment. Patients who experience febrile neutropenia may also require hospitalization and subsequent post-discharge care.1-7

Prevalence of Clinically Significant Febrile Neutropenia

An estimated 60,000 cancer patients in the United States were hospitalized for chemotherapy-induced febrile neutropenia in 1999.8

Dose Modification: Breast Cancer

View study results affecting the optimal delivery of chemotherapy in patients with breast cancer, in which neutropenia (both grade 3-4 and febrile) was the most frequent cause of chemotherapy dose delays and dose reductions.1,2

Dose Modification: Non-Hodgkin's Lymphoma

Neutropenia can impact chemotherapy delivery in patients with non-Hodgkin's lymphoma (NHL), causing dose delays and dose reductions.3

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References

  1. Lyman GH, Dale DC, Crawford J. Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices. J Clin Oncol. 2003;21:4524-4531.
  2. Link BK, Budd GT, Scott S, et al. Delivering adjuvant chemotherapy to women with early-stage breast carcinoma: current patterns of care. Cancer. 2001;92:1354-1367.
  3. Lyman G, Dale D, Friedberg J, Crawford J, Fisher R. Incidence and predictors of low chemotherapy dose-intensity in aggressive non-Hodgkin‘s lymphoma: a nationwide study. J Clin Oncol. 2004;22:4302-4311.
  4. Picozzi V, Pohlman B, Morrison V, et al. Patterns of chemotherapy administration in patients with intermediate-grade non-Hodgkin‘s lymphoma. Oncology. 2001;15:1296-1306.
  5. Vogel C, Wojtukiewicz M, Carroll R, et al. First and subsequent cycle use of pegfilgrastim prevents febrile neutropenia in patients with breast cancer: a multicenter, double-blind, placebo-controlled phase III study. J Clin Oncol. 2005;23:1178-1184.
  6. Neulasta® (pegfilgrastim) prescribing information, Amgen.
  7. Weycker D, Malin J, Edelsberg J, Glass A, Gokhale M, Oster G. Cost of neutropenic complications of chemotherapy. Ann Oncol. 2008;19:454-460.
  8. Caggiano V, Weiss R, Rickert T, Linde-Zwirble W. Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy. Cancer. 2005;103:1916-1924.